Variation of cysteine level by chlorobenzene-induced pertubation of glutathione metabolism in rat liver
M YOSHIDA, I HARA - Journal of Nutritional Science and …, 1985 - jstage.jst.go.jp
M YOSHIDA, I HARA
Journal of Nutritional Science and Vitaminology, 1985•jstage.jst.go.jp… It seems that the transsulfuration was not enhanced by the decrease in cysteine levels.
The results obtained in this study indicate that a depression of the oxidative degradation of
cysteine might be caused by the increase of the cysteine demand resulting from the
chlorobenzene-induced loss of hepatic glutathione. This supports a hypothesis proposed by
Kohashi et al.; cysteine dioxygenase may function as a valve for adjusting intracellular
pools of sulfur amino acids involving gluta thione (18). On the other hand, the enhancement …
The results obtained in this study indicate that a depression of the oxidative degradation of
cysteine might be caused by the increase of the cysteine demand resulting from the
chlorobenzene-induced loss of hepatic glutathione. This supports a hypothesis proposed by
Kohashi et al.; cysteine dioxygenase may function as a valve for adjusting intracellular
pools of sulfur amino acids involving gluta thione (18). On the other hand, the enhancement …
Summary
Effects of chlorobenzene-induced alteration in glutathione levels on cysteine metabolism in rat liver were investigated.
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